CRC as the third most common cancer and the second most common cause of death from cancer for both men and women.
Yet CRC is a highly treatable cancer if it is detected early and it is up to 95 per cent preventable with timely and thorough testing or "CRC screening". Unfortunately as it stands today, nearly half of those diagnosed find out too late.
The majority of CRCs begin as benign growths in the lining of the colon called adenomatous polyps. Over the years, these polyps grow in size and number, thereby increasing the risk that the cells in the polyps will become cancerous. Timely removal of these growths - easily done during a colonoscopy - will prevent CRC from developing. It is important to identify and remove these polyps as soon as possible.
Polyp removal is usually done during a colonoscopy and the patient is sedated during the procedure. Recovery is very quick and usually pain-free. Polyps are sent for a biopsy and tested for any malignancies.
Note: Many people diagnosed with CRC never had any symptoms or early warning signs. Above are the most common signs of CRC, but it is important to note that the symptoms are not unique to CRC - check with your doctor if you suspect a problem.
There is no "single cause" for developing CRC, but there some people who are considered to be at higher risk than the general population for CRC include:
If you are at higher risk, you should talk to your doctor about being screened as soon as possible.
The possibility of a diagnosis of advanced CRC in patients in their 40s is not uncommon and CRC has been seen in patients in their 20s. If you are concerned, get screened - there is not a health advantage to inaction.
Colorectal cancer (CRC) is the second leading cause of cancer death worldwide and in the US when combining men and women. Alarmingly, it’s now the top cause of cancer death in men under 50 and the second in women of the same age group. This shift shows CRC affecting people as early as their 30s and 40s—a trend researchers attribute to a mix of genetic and environmental factors. These may disrupt the gut microbiome (the genetic material of microorganisms in the intestines), altering the immune system and increasing CRC risk in younger adults.
CRC is largely preventable with regular screening, now recommended to begin at age 45 (previously 50) for those at average risk. Screening methods depend on your risk level:
Note: A positive FIT or Cologuard result requires a follow-up colonoscopy.
Action: Colonoscopy recommended.
Action: Colonoscopy recommended.
Action: Colonoscopy recommended before age 45, with timing based on family history.
AI-powered polyp detection systems are improving outcomes. Studies show endoscopists with high adenoma detection rates (ADR) during colonoscopies better protect against CRC. With AI assistance, ADR increases by 14.4%, and every 1% ADR boost lowers the risk of interval CRC (cancer between screenings) by 3%.
*Talk to your primary doctor today to schedule your screening.
Bal Raj Bhandari, M.D.